Product Name :
2-Fluoropalmitic acid (CAS 89270-22-4)
Synonym :
2-fluorohexadecanoic acid
Application :
2-Fluoropalmitic acid is an inhibitor of palmityl-CoA biosynthesis resulting in blockade of protein palmitoylation
CAS:
89270-22-4
Purity:
>98%
Molecular Weight:
274.42
Formula :
C16H31FO2
Physical state:
Solid
solubility :
Soluble in DMSO (10 mg/ml), 100% ethanol (10 mg/ml), DMF, and acetonitrile.
Shipping Condition :
Store at 4° C
Melting point:
84-86° C
SMILES:
CCCCCCCCCCCCCCC(C(=O)O)F
References:
:Novel bimodal effects of the G-protein tissue transglutaminase on adrenoreceptor signalling. | Zhang, J., et al. 1999. Biochem J. 343 Pt 3: 541-9. PMID: 10527931Very-long-chain and branched-chain fatty acyl-CoAs are high affinity ligands for the peroxisome proliferator-activated receptor alpha (PPARalpha). | Hostetler, HA., et al. 2006. Biochemistry. 45: 7669-81. PMID: 16768463Palmitoylation controls recycling in lysosomal sorting and trafficking. | McCormick, PJ., et al. 2008. Traffic. 9: 1984-97. PMID: 18817523Bovine beta-lactoglobulin acts as an acid-resistant drug carrier by exploiting its diverse binding regions. | Barbiroli, A., et al. 2010. Biol Chem. 391: 21-32.120042-11-7 structure PMID: 19919177pH-triggered release from nonphospholipid LUVs modulated by the pKa of the included fatty acid.1234616-13-7 Order | Phoeung, T.PMID:33547856 , et al. 2010. Langmuir. 26: 12769-76. PMID: 20666419Metabolic activation of 2-substituted derivatives of myristic acid to form potent inhibitors of myristoyl CoA:protein N-myristoyltransferase. | Paige, LA., et al. 1990. Biochemistry. 29: 10566-73. PMID: 2271666G protein-membrane interactions I: G alpha i1 myristoyl and palmitoyl modifications in protein-lipid interactions and its implications in membrane microdomain localization. | Álvarez, R., et al. 2015. Biochim Biophys Acta. 1851: 1511-20. PMID: 26253820Chlamydia trachomatis growth and development requires the activity of host Long-chain Acyl-CoA Synthetases (ACSLs). | Recuero-Checa, MA., et al. 2016. Sci Rep. 6: 23148. PMID: 26988341Association of long-chain acyl-coenzyme A synthetase5 expression in human breast cancer by estrogen receptor status and its clinical significance. | Yen, MC., et al. 2017. Oncol Rep. 37: 3253-3260. PMID: 28498416Identification of 2-Fluoropalmitic Acid as a Potential Therapeutic Agent Against Glioblastoma. | Jiapaer, S., et al. 2020. Curr Pharm Des. 26: 4675-4684. PMID: 32348209Therapeutic Perspective of Temozolomide Resistance in Glioblastoma Treatment. | Xia, Q., et al. 2021. Cancer Invest. 39: 627-644. PMID: 34254870Regulation of a sodium channel-associated G-protein by aldosterone. | Rokaw, MD., et al. 1996. J Biol Chem. 271: 4491-6. PMID: 8626803Mycolic acid biosynthesis: definition and targeting of the Claisen condensation step. | Lee, RE., et al. 1997. Biochim Biophys Acta. 1346: 275-84. PMID: 9219912