Product Name :
SREBP1 Rabbit Polyclonal Antibody
Predicted band size :
Observed band size :
Synonyms:
ADD 1 antibody bHLHd1 antibody Class D basic helix-loop-helix protein 1 antibody D630008H06 antibody Processed sterol regulatory element-binding protein 1 antibody SRBP1_HUMAN antibody SREBF 1 antibody SREBF1 antibody SREBP 1 antibody SREBP 1c antibody 展开
Function :
This gene encodes a basic helix-loop-helix-leucine zipper (bHLH-Zip) transcription factor that binds to the sterol regulatory element-1 (SRE1), which is a motif that is found in the promoter of the low density lipoprotein receptor gene and other genes involved in sterol biosynthesis. The encoded protein is synthesized as a precursor that is initially attached to the nuclear membrane and endoplasmic reticulum. Following cleavage, the mature protein translocates to the nucleus and activates transcription. This cleaveage is inhibited by sterols. This gene is located within the Smith-Magenis syndrome region on chromosome 17.tert-Butyl 2-aminoacetate site Alternative promoter usage and splicing result in multiple transcript variants, including SREBP-1a and SREBP-1c, which correspond to RefSeq transcript variants 2 and 3, respectively.
Antibody Type:
Rabbit Polyclonal Antibody
Immunogen :
Synthetic peptide within N-terminal human SREBP1 from aa25-aa55.
Species reactivity:
Human, Mouse
Verify application:
WB, IF-Cell, IHC-P
Coupling :
unconjugated
Clone number:
RRID:
AB_3071307
Form :
Liquid
Concentration :
1ug/ul
Storage instructions:
Store at +4℃ after thawing.4-Nitrobutan-1-ol custom synthesis Aliquot store at -20℃.PMID:33459176 Avoid repeated freeze / thaw cycles.
Storage buffer solution:
1*TBS (pH7.4), 0.2% BSA, 50% Glycerol. Preservative: 0.05% Sodium Azide.
Subtype:
IgG
Purification method :
Immunogen affinity purified.
ELTSA :
Molecular weight :
122 kDa
Positive control :
HepG2 cell lysate, mouse heart tissue lysate, mouse liver tissue lysate, 293 cell lysate, Jurkat cell lysate, A549 cell lysate, Hela, human lung tissue, human placenta tissue.