Product Name :
Olig2 Recombinant Rabbit Monoclonal Antibody [SP07-02]
Predicted band size :
32 kDa
Observed band size :
36 kDa
Synonyms:
Basic domain helix loop helix protein class B 1 antibody Basic helix loop helix protein class B 1 antibody BHLHB antibody bHLHB1 antibody bHLHe19 antibody Class B basic helix loop helix protein 1 antibody Class B basic helix-loop-helix protein 1 antibody class E basic helix loop helix protein 19 antibody Class E basic helix-loop-helix protein 19 antibody Human protein kinase C binding protein RACK17 antibody 展开
Function :
The oligodendrocyte lineage-specific basic helix-loop-helix (OLIG) family of transcription factors include OLIG1-OLIG3, which differ in tissue expression.2-(Aminooxy)ethanamine dihydrochloride web OLIG1 and OLIG2 are specifically expressed in nervous tissue as gene regulators of oligodendrogenesis.Buy((2-Iodoethoxy)methyl)benzene OLIG2 is more widely expressed in embryonic brain than OLIG1, while OLIG3 is primarily expressed in non-neural tissues.PMID:33749571 OLIG1 and OLIG2 interact with the Nkx-2.2 homeodomain protein, which is responsible for directing ventral neuronal patterning in response to graded Sonic hedgehog signaling in the embryonic neural tube. These interactions between OLIG proteins and Nkx-2.2 appear to promote the formation of alternate cell types by inhibiting V3 interneuron development. OLIG1 and OLIG2 are abundantly expressed in oligodendroglioma and nearly absent in astrocytomas. Therefore, OLIG proteins are candidates for molecular markers of human glial brain tumors, which are the most common primary malignancies of the human brain.
Antibody Type:
Recombinant Rabbit monoclonal Antibody
Immunogen :
Synthetic peptide within Human Olig2 aa 238-287 / 323.
Species reactivity:
Human, Mouse, Rat
Verify application:
WB, IHC-P, IHC-Fr, IF-Tissue, mIHC
Coupling :
unconjugated
Clone number:
SP07-02
RRID:
AB_3069693
Form :
Liquid
Concentration :
1ug/ul
Storage instructions:
Store at +4℃ after thawing. Aliquot store at -20℃ or -80℃. Avoid repeated freeze / thaw cycles.
Storage buffer solution:
1*TBS (pH7.4), 0.05% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.
Subtype:
IgG
Purification method :
Protein A affinity purified.
ELTSA :
Molecular weight :
Predicted band size: 32 kDa
Positive control :
Mouse brain tissue lysate, rat brain tissue lysate, human brain tissue lysate, mouse cerebral cortex tissue, human glioma tissue, human brain tissue, rat brain tissue, mouse brain tissue, mouse hippocampus tissue, E14.5 mouse embryonic brain tissue.