Pegpolymer

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RBCK1/HBV associated factor 4 Rabbit Polyclonal Antibody

By Chemexpress

Product Name :
RBCK1/HBV associated factor 4 Rabbit Polyclonal Antibody

Predicted band size :

Observed band size :

Synonyms:
C20orf18 antibody Chromosome 20 open reading frame 18 antibody HBV associated factor 4 antibody HBV-associated factor 4 antibody Heme-oxidized IRP2 ubiquitin ligase 1 antibody Hepatitis B virus X associated protein 4 antibody Hepatitis B virus X-associated protein 4 antibody HOIL 1L antibody HOIL-1 antibody HOIL-1L antibody 展开

Function :
Acts as an E3 ubiquitin-protein ligase, or as part of an E3 complex, which accepts ubiquitin from specific E2 ubiquitin-conjugating enzymes, such as UBE2L3/UBCM4, and then transfers it to substrates. Functions as an E3 ligase for oxidized IREB2 and both heme and oxygen are necessary for IREB2 ubiquitination. Promotes ubiquitination of TAB2 and IRF3 and their degradation by the proteoasome. Component of the LUBAC complex which conjugates linear polyubiquitin chains in a head-to-tail manner to substrates. LUBAC conjugates linear polyubiquitin to IKBKG at ‘Lys-285’ and ‘Lys-309’ and is involved in activation of the canonical NF-kappa-B and the JNK signaling pathways. LUBAC is proposed to be recruited to the TNF-R1 signaling complex (TNF-RSC) following polyubiquitination of TNF-RSC components by BIRC2 and/or BIRC3 and to conjugate linear polyubiquitin to IKBKG and possibly other components contributing to the stability of the complex. Binds polyubiquitin of different linkage types.

Antibody Type:
Rabbit Polyclonal Antibody

Immunogen :
KLH conjugated synthetic peptide derived from human RBCK1/HBV associated factor 4 251-350/510

Species reactivity:
Human, Mouse, Rat, Dog, Cow, Rabbit, Sheep

Verify application:
WB, ELISA, IHC-P, IF, ICC

Coupling :
unconjugated

Clone number:

RRID:

Form :
Liquid

Concentration :
1ug/ul

Storage instructions:
Store at -20℃ for one year.2,4-Dichloro-5-fluoro-6-methylpyrimidine Data Sheet Avoid repeated freeze/thaw cycles.BuyFmoc-Cha-OH The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20℃.PMID:33648410 When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4℃.

Storage buffer solution:
0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.

Subtype:
IgG

Purification method :
Protein A affinity purified.

ELTSA :

Molecular weight :
56 KDa

Positive control :

By Chemexpress

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