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PI 3 Kinase p110 delta Recombinant Rabbit Monoclonal Antibody [JM83-24]

By Chemexpress

Product Name :
PI 3 Kinase p110 delta Recombinant Rabbit Monoclonal Antibody [JM83-24]

Predicted band size :
119 kDa

Observed band size :
105 kDa

Synonyms:
5-bisphosphate 3-kinase 110 kDa catalytic subunit delta antibody 5-bisphosphate 3-kinase catalytic subunit delta isoform antibody APDS antibody GRB1 antibody IMD14 antibody p110d antibody p110delta antibody p110dp85a antibody p85-ALPHA antibody Phosphatidylinositol 3 kinase catalytic delta polypeptide antibody 展开

Function :
Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta isoform also known as phosphoinositide 3-kinase (PI3K) delta isoform or p110δ is an enzyme that in humans is encoded by the PIK3CD gene. p110δ regulates immune function. In contrast to the other class IA PI3Ks p110α and p110β, p110δ is principally expressed in leukocytes (white blood cells). Genetic and pharmacological inactivation of p110δ has revealed that this enzyme is important for the function of T cells, B cell, mast cells and neutrophils. Hence, p110δ is a promising target for drugs that aim to prevent or treat inflammation, autoimmunity and transplant rejection. Phosphoinositide 3-kinases (PI3Ks) phosphorylate the 3-prime OH position of the inositol ring of inositol lipids. The class I PI3Ks display a broad phosphoinositide lipid substrate specificity and include p110α, p110β and p110γ. p110α and p110β interact with SH2/SH3-domain-containing p85 adaptor proteins and with GTP-bound Ras.

Antibody Type:
Recombinant Rabbit monoclonal Antibody

Immunogen :
Synthetic peptide within Human PI 3 Kinase p110 delta aa 197-246 / 1044.

Species reactivity:
Human, Mouse, Rat

Verify application:
WB, IHC-P

Coupling :
unconjugated

Clone number:
JM83-24

RRID:
AB_3070573

Form :
Liquid

Concentration :
1ug/ul

Storage instructions:
Store at +4℃ after thawing.Price of Palladium (trifluoroacetate) Aliquot store at -20℃ or -80℃.248274-16-0 uses Avoid repeated freeze / thaw cycles.PMID:33715515

Storage buffer solution:
1*TBS (pH7.4), 0.05% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.

Subtype:
IgG

Purification method :
Protein A affinity purified.

ELTSA :

Molecular weight :
Predicted band size: 119 kDa

Positive control :
Mouse spleen tissue lysates, rat spleen tissue lysates, human tonsil tissue, human spleen tissue.

By Chemexpress

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